Clinical Investigation

Evaluation of the Effects of Remifentanyl and Alfentanyl on Spirometric Parameters in Endotracheal Intubations

  • Erdal GEZER
  • Selda SEN
  • Bakiye UGUR
  • Osman Nuri AYDIN
  • Mustafa OGURLU
  • Feray GÜRSOY

Meandros Med Dent J 2006;7(2):37-41

Objective: The aim of this study was to evaluate respiratory changes on spirometry which occur in response to endotracheal intubations in patients receiving remifentanyl and alfentanyl. Materials and methods: This is a retrospective study. Spirometric data were derived from anaesthesia monitoring forms in patient files. The study included 40 patients aged between 18 and 60 years. They were assigned into two groups i.e. Group remifentanyl (R) (n=20) and Group alfentanyl (A) (n=20). Group R received intravenous bolus 1 µg/kg remifentanyl before intubations and 0.25 µg/kg/min remifentanyl after intubations and Group A received IV bolus 20 µg/kg alfentanyl before intubations and 1 µg/kg/min alfentanyl after intubations. Peak inspiratory pressure (PIP), plateau pressure (Pplateau), airway resistance (Raw) and pulmonary compliance (C) measured just before and soon after Remifentanyl and Alfentanyl were given and in the intraoperative fifth and tenth minutes were obtained. Results: There was no significant difference in peak inspiratory pressure, plateau pressure and pulmonary compliance between the groups, but the difference in baseline airway resistance between the groups was significant (P Conclusion: It can be concluded that remifentanyl and alfentanyl do not cause respiratory side-effects in patients who undergo elective operations and can be administered safely for general anesthesia.

Keywords: Remifentanyl, alfentanyl, spirometric parameters