Clinical Investigation

Efficacy Of Prophylaxis With Norfloxacin in Transrectal Prostate Biopsy

  • Ömer ÖGE
  • Hakan GEMALMAZ
  • Izzet KOÇAK
  • Burçin ÖZEREN
  • Mete EYIGÖR
  • Haluk EROL

Received Date: 25.02.2000 Accepted Date: 05.05.2000 Meandros Med Dent J 2000;1(2):5-7

Objective: Transrectal needle biopsy is the standard method in the diagnosis of prostate cancer. Various antibi-otic regimens have been used to reduce the complication of infection associated with this procedure. However, there is no well-established antibiotic regimen for patients undergoing transrectal biopsy of the prostate. Methods: Thirty-four patients undergoing transrectal biopsies of the prostate received 400 mg of norfloxacin twice a day starting 24 h before biopsy and continued for 1 week. In 48 hours and 7th day after transrectal needle biopsy were provided urine culture. Significant bacteriuria was defined as more than 1x105 colony / mL and febrile attack was accepted as high fever reaching 38.5°C. Results: Each rates of bacteraemia and urinary tract infection were 3%, and no patient developed sepsis. Discussion: The development of infection after transrectal biopsy of prostate is not rare. With the purpose of preventing such complications, intravenous antibiotics in high cost are commonly used. Norfloxacin prophylaxis for 1 week effectively minimizes such complications and it also has a low cost.

Keywords: norfloxacin, prostate, biopsy