Clinical Investigation

Preemptive Analgesic Properties of Ketamine on Tonsillectomy Surgery

  • Osman Nuri AYDIN
  • Bakiye UGUR
  • Sanem ÖZGÜN
  • Hülya EYIGÖR
  • Özgen COPCU

Received Date: 18.02.2004 Accepted Date: 24.05.2004 Meandros Med Dent J 2004;5(3):15-20

Objectives: The aim was to evaluate the preemptive analgesic effects of ketamine was used in different stages of surgery. Method: All of the patients/parents were informed and The Ethical Committee of the Medical Faculty approved the study. Ninety patients (ages, 5-15) divided into three groups. The pre-emptive group (Group P, n=30) received intravenous (IV) ketamine 0,5mg/kg in 2mL saline at tonsillectomy position, followed by a continuous infusion of ketamine 6?g/kg/min, and 2 mL saline was administered during homeostasis. In the ketamine group (Group K, n=30), 2 mL saline was given at tonsillectomy position, and saline infusion (10 mL/h) continued until homeostasis, and 0,8 mg/kg examine was given during homeostasis in 2 mLsaline. In the control group (Group C, n=30) saline was given at all stages of study. When VPS is greater than 3; tramadol 1 mg/kg IV administered in the first 6 hours postoperatively, and after paracetamol orally, 40mg/kg was given. Cardiorespiratory system data, recovery from anaesthesia and discharging parameters, tramadol and paracetamol requirement, total dose of paracetamol, and complications were recorded. Results: Recovery from anesthesia and discharging parameters were similar between the groups. In the preemptive group, VPS scores were lower than the other two groups at the early postoperative period, and at 4th, hours. The VPS scores were higher in the control group than the other two groups at 6th hour (P Conclusion: Ketamine decreases postoperative analgesic requirement and has preemptive analgesic effect when used before surgery in tonsillectomy/adenotonsillectomy surgery.

Keywords: Ketamine, tonsillectomy, preemptive analgesia, postop. analgesic requirement