Case Report

A Case Of Severe Combined Immunodeficiency

  • Nesrin GÜLEZ
  • Hasan AGIN
  • Sebnem ÇALKAVUR
  • Yesim ERGÜDENLER
  • Ferah GENEL
  • Mustafa BAK

Received Date: 25.04.2002 Accepted Date: 09.05.2003 Meandros Med Dent J 2003;4(3):25-27

Severe combined immunodeficiency (SCID) is a heterogeneous group of inherited disorders characterized by profound abnormalities in T, B and natural killer cell development and function, resulting in failure of both cellular and humoral immunity. The age of presentation is variable but occurs typically between 3 and 6 months. The major clinical manifestations include recurrent diarrhea, persistant oral candidiasis, pneumonia, recurrent otitis media, cutaneous fungal infections and sepsis. Opportunistic infection induced end organ damage, particularly to the lungs and liver, is associated with greatly increased morbidity and mortality. Therefore SCID has been described as a pediatric emergency. Inthis article a 5-month-old female infant admitted with the complaint of recurrent respiratory infections and disseminated fungal infections and diagnosed as severe combined immunodeficiency (SCID) is presented.

Keywords: Severe combined immunodeficiency, respiratory infection, fungal infection